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KMID : 0381219930250030175
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Journal of RIMSK
1993 Volume.25 No. 3 p.175 ~ p.182
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Experimental Study of the Influence of Intravesical Interferon-αon the Epithelial Regeneration of the Urinary Bladder in Rats
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Abstract
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The effects of interferon alpha(IFN-α) on regeneration of urinary bladder epithelium were studied in rats. Mucosal dendation of the bladder was induced in 18 rats by intravesical instillation of 0.1 N hydrochloride solution. Among them, 2 rats
were
sacrificed immediately and each week 2 rats were also sacrificed for 3 weeks(Group A). Intravesical instillation of IFN-α was performed only one time in 6 rats and each week 2 rats were sacrificed for 3 weeks(Group B). Intravesical instillation
of
IFN-α was performed weekly in 4 rats and they and they were sacrificed 3 weeks later (Group C). Normal bladder of 4 rats without any treatment were used as control.
Histopathological examination of the bladders under light microscope showed that complete regeneration of epithelium developed within 3 weeks after the induction of denudation of mucosa in Group A, as well as B and C. There were no differences in
the
morphological apperance and the speed of regeneration of rat bladder epithelium among Group A, B and C. these results suggest that IFN-α may have no definitive role in the regeneration of rat bladder epithelium.
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KEYWORD
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